Fentanyl withdrawal Onset is faster and symptoms can be more intense, but the timeline is similar.

Fentanyl's short half-life means withdrawal onset within 6–12 hours of last use — faster than heroin. Symptoms peak at 48–72 hours.

MAT (buprenorphine) requires careful induction to avoid precipitated withdrawal, especially with fentanyl.

Detox coordination and outpatient MAT together shorten the misery meaningfully.